Left ventricular response to short exercise in long term non-hodgkin lymphoma survivors

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Echocardiographic left ventricular (LV) global longitudinal strain (GLS) may be used to detect subclinical dysfunction in patients who have received cardiotoxic chemotherapy. However, some persons participating recreational sports, GLS at rest lower than normal, but normalizes after a short exercise test as soon resting heart rate (HR) is reached. The aim the study was determine response treated for aggressive non- Hodgkin Lymphoma (NHL) compared controls. Methods We conducted cross-sectional nested cohort NHL survivors and their siblings served controls . Survivors were 5 years ago or longer with cumulative doxorubicin (anthracycline) dose least 250 mg/m2. Transthoracic Echocardiography (TTE) performed according guidelines. First, LV ejection fraction (EF) measured rest. After 20 squats, EF measurements repeated when HR comparable during measurements. Results In total (mean age 49 (± 13) years, 11 men (55%) included 14 45 8) 8 ( 57 %). rest, 52.6% ± 8.0%) −16.1% 2.9%), an 56.2% 3.4% ) (p-value 0.13) −18.0% 1.4 %) 0.031). All squats increased 55.0% 6.8%) −18.7% 3.8%) whom 62% 4.7%) 0.002) −21.3% 2.5%) 0.037) (Figure 1). Conclusion addition measurement seems promising tool non-Hodgkin survivors. Further research larger studies needed confirm these findings assess association clinical parameters.